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Kohei Kaku Selected Research

Pioglitazone (Actos)

11/2020Comparison of the effects of three kinds of glucose-lowering drugs on non-alcoholic fatty liver disease in patients with type 2 diabetes: A randomized, open-label, three-arm, active control study.
3/2015Evaluation of the long-term durability and glycemic control of fasting plasma glucose and glycosylated hemoglobin for pioglitazone in Japanese patients with type 2 diabetes.
2/2013A multicenter, phase III evaluation of the efficacy and safety of a new fixed-dose pioglitazone/glimepiride combination tablet in Japanese patients with type 2 diabetes.
6/2012Efficacy and tolerability of rosiglitazone and pioglitazone in drug-naïve Japanese patients with type 2 diabetes mellitus: a double-blind, 28 weeks' treatment, comparative study.
11/2011Efficacy and safety of combination therapy with candesartan cilexetil and pioglitazone hydrochloride in patients with hypertension and type 2 diabetes mellitus.
11/2010Long-term effects of pioglitazone on carotid atherosclerosis in Japanese patients with type 2 diabetes without a recent history of macrovascular morbidity.
12/2009Long-term effects of pioglitazone in Japanese patients with type 2 diabetes without a recent history of macrovascular morbidity.
5/2009Efficacy and safety of therapy with metformin plus pioglitazone in the treatment of patients with type 2 diabetes: a double-blind, placebo-controlled, clinical trial.
1/2009Addition of mitiglinide to pioglitazone monotherapy improves overall glycemic control in Japanese patients with type 2 diabetes: a randomized double blind trial.
3/2005Structural and functional analysis of pancreatic islets preserved by pioglitazone in db/db mice.

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Kohei Kaku Research Topics

Disease

138Type 2 Diabetes Mellitus (MODY)
04/2024 - 08/2002
24Diabetes Mellitus
11/2023 - 08/2002
24Hypoglycemia (Reactive Hypoglycemia)
12/2022 - 06/2010
23Body Weight (Weight, Body)
03/2024 - 06/2004
21Insulin Resistance
03/2024 - 03/2005
15Hyperglycemia
01/2023 - 07/2013
14Type 1 Diabetes Mellitus (Autoimmune Diabetes)
11/2022 - 01/2009
13Atherosclerosis
03/2024 - 04/2010
8Neoplasms (Cancer)
01/2023 - 01/2016
8Weight Loss (Weight Reduction)
09/2021 - 01/2019
8Diabetic Nephropathies (Diabetic Nephropathy)
09/2019 - 08/2002
7Infections
10/2022 - 10/2018
6Obesity
03/2024 - 04/2016
6Hypertension (High Blood Pressure)
09/2023 - 11/2011
6Drug-Related Side Effects and Adverse Reactions
07/2023 - 09/2016
6Edema (Dropsy)
09/2022 - 01/2009
6Weight Gain
09/2021 - 01/2009
6Glucose Intolerance
03/2015 - 08/2008
5Inflammation (Inflammations)
03/2024 - 01/2019
5Urinary Tract Infections (Urinary Tract Infection)
07/2023 - 10/2017
5Hypertriglyceridemia
07/2023 - 11/2007
5Cardiovascular Diseases (Cardiovascular Disease)
01/2022 - 04/2010
4Fatty Liver
03/2024 - 07/2016
4Pain (Aches)
12/2023 - 01/2016
4Dyslipidemias (Dyslipidemia)
09/2023 - 08/2019
4Hypothyroidism
01/2023 - 01/2022
4Cushing Syndrome
10/2022 - 01/2017
4Diabetic Ketoacidosis (Ketoacidosis, Diabetic)
10/2022 - 02/2020
4Graves Disease (Basedow Disease)
09/2022 - 12/2016
4Carotid Artery Diseases
02/2019 - 11/2010
3Chronic Renal Insufficiency
11/2023 - 06/2021
3Hypophosphatemia
12/2022 - 01/2016
3Diabetes Complications
10/2022 - 01/2022
3Hypersensitivity (Allergy)
10/2022 - 01/2009
3Diabetic Neuropathies (Diabetic Neuropathy)
01/2022 - 05/2015
3Heart Failure
01/2022 - 01/2017
3Arteriosclerosis
07/2021 - 11/2017
3Non-alcoholic Fatty Liver Disease
06/2021 - 01/2019

Drug/Important Bio-Agent (IBA)

57Glucose (Dextrose)FDA LinkGeneric
03/2024 - 06/2004
51Insulin (Novolin)FDA Link
04/2024 - 08/2008
27Hypoglycemic Agents (Hypoglycemics)IBA
11/2023 - 01/2009
216- ((4- ethylphenyl)methyl)- 3',4',5',6'- tetrahydro- 6'- (hydroxymethyl)spiro(isobenzofuran- 1(3H),2'- (2H)pyran)- 3',4',5'- triolIBA
11/2023 - 03/2014
20Sodium-Glucose Transporter 2 InhibitorsIBA
03/2024 - 11/2013
18SodiumIBA
07/2023 - 07/2013
12LipidsIBA
11/2023 - 08/2002
12Sodium-Glucose Transport ProteinsIBA
01/2020 - 04/2014
11Dipeptidyl-Peptidase IV InhibitorsIBA
03/2024 - 02/2014
11Blood Glucose (Blood Sugar)IBA
03/2024 - 09/2009
10Pioglitazone (Actos)FDA Link
11/2020 - 03/2005
9Glycated Hemoglobin (Glycosylated Hemoglobin)IBA
02/2021 - 06/2012
8empagliflozinIBA
07/2023 - 01/2017
8IncretinsIBA
03/2022 - 07/2013
8insulin degludecIBA
03/2022 - 01/2013
8trelagliptinIBA
03/2020 - 02/2014
8LiraglutideFDA Link
12/2019 - 08/2011
7Glucagon-Like Peptide-1 ReceptorIBA
01/2024 - 11/2017
7Hydrocortisone (Cortisol)FDA LinkGeneric
01/2023 - 01/2015
7ipragliflozinIBA
12/2021 - 07/2018
7Sitagliptin Phosphate (Januvia)FDA Link
01/2021 - 11/2013
7alogliptinIBA
11/2019 - 09/2011
6Adrenocorticotropic Hormone (ACTH)FDA Link
01/2023 - 01/2015
6AntibodiesIBA
01/2023 - 04/2019
51,5- anhydro- 1- (5- (4- ethoxybenzyl)- 2- methoxy- 4- methylphenyl)- 1- thioglucitolIBA
03/2024 - 01/2015
5imegliminIBA
03/2024 - 01/2022
5Transcription Factors (Transcription Factor)IBA
01/2023 - 01/2005
5Thyrotropin (Thyroid-Stimulating Hormone)FDA Link
01/2023 - 01/2021
5SymportersIBA
01/2022 - 12/2014
5Glucagon-Like Peptide 1 (GLP 1)IBA
07/2021 - 08/2011
5Metformin (Glucophage)FDA LinkGeneric
03/2021 - 05/2009
5voglibose (Basen)IBA
06/2014 - 05/2009
4Lipoproteins (Lipoprotein)IBA
07/2023 - 08/2002
4CholesterolIBA
01/2023 - 05/2009
4Thyroxine (Levothyroxine)FDA LinkGeneric
01/2023 - 01/2021
4C-Reactive ProteinIBA
09/2022 - 03/2016
4SteroidsIBA
01/2022 - 01/2015
4glimepiride (Amarel)FDA LinkGeneric
11/2020 - 12/2012
4AdiponectinIBA
11/2020 - 05/2009
4CanagliflozinIBA
01/2020 - 12/2015
4Insulin Glargine (Lantus)FDA Link
01/2018 - 01/2013
4mitiglinideIBA
06/2014 - 01/2009
4Rosuvastatin Calcium (Crestor)FDA Link
01/2014 - 04/2010
3C-PeptideIBA
04/2024 - 08/2008
3Apolipoproteins E (ApoE)IBA
03/2024 - 08/2002
3Biomarkers (Surrogate Marker)IBA
03/2024 - 06/2016
3Hemoglobins (Hemoglobin)IBA
03/2024 - 11/2016
3semaglutideIBA
01/2024 - 01/2018
3dulaglutideIBA
01/2024 - 01/2021
3ApolipoproteinsIBA
12/2023 - 08/2002
3EnzymesIBA
11/2023 - 07/2013
3Hormones (Hormone)IBA
01/2023 - 01/2015
3Immune Checkpoint InhibitorsIBA
01/2023 - 01/2021
3Thyroid HormonesIBA
01/2023 - 01/2022
3Proteins (Proteins, Gene)FDA Link
12/2022 - 01/2005
3Anti-Bacterial Agents (Antibiotics)IBA
07/2021 - 01/2019
3Triglycerides (Triacylglycerol)IBA
06/2021 - 01/2016
3Nonesterified Fatty Acids (NEFA)IBA
01/2020 - 05/2009

Therapy/Procedure

69Therapeutics
04/2024 - 01/2009
39Glycemic Control
03/2024 - 01/2009
5Exercise Therapy (Therapy, Exercise)
03/2020 - 11/2011
3Renal Dialysis (Hemodialysis)
03/2020 - 01/2016